SidaGhanaV1, Main, Exploration, bibRecord, 001536

Genomic divergence of HIV-2 from Ghana.

Identifieur interne : 001536 ( Main/Exploration ); précédent : 001535; suivant : 001537

Genomic divergence of HIV-2 from Ghana.

Auteurs : A. Hasegawa [Japon] ; H. Tsujimoto ; N. Maki ; K. Ishikawa ; T. Miura ; M. Fukasawa ; K. Miki ; M. Hayami

Source :

AIDS research and human retroviruses [ 0889-2229 ] ; 1989.

RBID : pubmed:2611042

Descripteurs français

KwdFr :
- ADN viral (génétique), Cartographie de restriction, Données de séquences moléculaires, Ghana, Gènes viraux, Humains, Similitude de séquences d'acides nucléiques, Séquence d'acides aminés, Séquence nucléotidique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (génétique), VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (isolement et purification), Variation génétique, Virus de l'immunodéficience simienne (génétique).
MESH :
- génétique : ADN viral, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), VIH-2 (Virus de l'Immunodéficience Humaine de type 2), Virus de l'immunodéficience simienne.
- isolement et purification : VIH-2 (Virus de l'Immunodéficience Humaine de type 2).
- Cartographie de restriction, Données de séquences moléculaires, Ghana, Gènes viraux, Humains, Similitude de séquences d'acides nucléiques, Séquence d'acides aminés, Séquence nucléotidique, Variation génétique.
Wicri :
- geographic : Ghana.

English descriptors

KwdEn :
- Amino Acid Sequence, Base Sequence, DNA, Viral (genetics), Genes, Viral, Genetic Variation, Ghana, HIV-1 (genetics), HIV-2 (genetics), HIV-2 (isolation & purification), Humans, Molecular Sequence Data, Restriction Mapping, Sequence Homology, Nucleic Acid, Simian Immunodeficiency Virus (genetics).
MESH :
- chemical , genetics : DNA, Viral.
- geographic : Ghana.
- genetics : HIV-1, HIV-2, Simian Immunodeficiency Virus.
- isolation & purification : HIV-2.
- Amino Acid Sequence, Base Sequence, Genes, Viral, Genetic Variation, Humans, Molecular Sequence Data, Restriction Mapping, Sequence Homology, Nucleic Acid.

Abstract

Genetic variability in human immunodeficiency virus type 1 (HIV-1) has been studied extensively, but the total nucleotide sequence of the HIV-2 genome has been reported only in two strains. For phylogenetic analyses of HIV, the genetic variability of HIV-2 should be investigated. This paper reports the complete nucleotide sequence of an HIV-2 isolate from Ghana, HIV-2[GH-1]. This virus showed approximately 85% homology in overall nucleotide sequence with HIV-2ROD. The amino acid sequence of the gag and pol proteins of HIV-2[GH-1] showed 90% homology with those of HIV-2ROD, but its env gene and central regions were highly variable (more than 20% divergence in amino acids), indicating the presence of extensive genetic heterogeneity in HIV-2. However, the sequences with specific functions were relatively well conserved in these HIV-2 isolates.

DOI: 10.1089/aid.1989.5.593
PubMed: 2611042

Affiliations:

Japon

Le document en format XML

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<term>Base Sequence</term>
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<term>Genes, Viral</term>
<term>Genetic Variation</term>
<term>Ghana</term>
<term>HIV-1 (genetics)</term>
<term>HIV-2 (genetics)</term>
<term>HIV-2 (isolation & purification)</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Restriction Mapping</term>
<term>Sequence Homology, Nucleic Acid</term>
<term>Simian Immunodeficiency Virus (genetics)</term>
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<term>Cartographie de restriction</term>
<term>Données de séquences moléculaires</term>
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<term>Gènes viraux</term>
<term>Humains</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term>
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<term>Variation génétique</term>
<term>Virus de l'immunodéficience simienne (génétique)</term>
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<term>Genetic Variation</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Restriction Mapping</term>
<term>Sequence Homology, Nucleic Acid</term>
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<term>Données de séquences moléculaires</term>
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<term>Gènes viraux</term>
<term>Humains</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
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<front><div type="abstract" xml:lang="en">Genetic variability in human immunodeficiency virus type 1 (HIV-1) has been studied extensively, but the total nucleotide sequence of the HIV-2 genome has been reported only in two strains. For phylogenetic analyses of HIV, the genetic variability of HIV-2 should be investigated. This paper reports the complete nucleotide sequence of an HIV-2 isolate from Ghana, HIV-2[GH-1]. This virus showed approximately 85% homology in overall nucleotide sequence with HIV-2ROD. The amino acid sequence of the gag and pol proteins of HIV-2[GH-1] showed 90% homology with those of HIV-2ROD, but its env gene and central regions were highly variable (more than 20% divergence in amino acids), indicating the presence of extensive genetic heterogeneity in HIV-2. However, the sequences with specific functions were relatively well conserved in these HIV-2 isolates.</div>
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Le SIDA au Ghana (serveur d'exploration)

Genomic divergence of HIV-2 from Ghana.

Genomic divergence of HIV-2 from Ghana.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Le SIDA au Ghana (serveur d'exploration)
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